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Literature summary extracted from

  • Piovan, L.; Alves, M.F.; Juliano, L.; Broemme, D.; Cunha, R.L.; Andrade, L.H.
    Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S (2011), Bioorg. Med. Chem., 19, 2009-2014.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.43 (1R)-1-{2-[butyl(dichloro)-l4-tellanyl]phenyl}ethyl methyl ether less than 10% residual activity at 0.001 mM Homo sapiens
3.4.22.43 (1R)-1-{2-[dibromo(butyl)-l4-tellanyl]phenyl}ethyl methyl ether less than 10% residual activity at 0.001 mM Homo sapiens
3.4.22.43 (1S)-1-{2-[butyl(dichloro)-l4-tellanyl]phenyl}ethyl methyl ether less than 10% residual activity at 0.001 mM Homo sapiens
3.4.22.43 (1S)-1-{2-[dibromo(butyl)-l4-tellanyl]phenyl}ethyl methyl ether less than 10% residual activity at 0.001 mM Homo sapiens
3.4.22.43 2-[butyl(dichloro)-l4-tellanyl]benzyl methyl ether about 10% residual activity at 0.001 mM Homo sapiens
3.4.22.43 2-[dibromo(butyl)-l4-tellanyl]benzyl methyl ether less than 10% residual activity at 0.001 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.43 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.43 Cbz-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Cbz-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?